Sanofi

Aventis Pharma S.a.

Innate Pharma

Marielle Chiron

Laurent Gauthier

Angela Virone-Oddos

Patrick Mailliet

Nicolas Gourdin

Cécile Combeau

Alessandro Masiero

Sambasiva Rao

Leila Sevigny

Yanfeng Zhou

Ingo Focken

Jochen Beninga

Alexandre Tang

The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-γ receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).

Natural killer (NK) cell engagers binding to NKp46 and BCMA variants with Fc-engineering

The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human CD123 and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof to a human Fc-&#x3b3; receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including Acute Myeloid Leukemia (AML) and myelodysplastic syndromes (MDS).

Multifunctional natural killer (NK) cell engagers binding to NKp46 and CD123

The invention relates to compounds of formula (I)in which Ris chosen from the group consisting of:in which Ris a C-Calkyl groupin which X may be Cl, Br, or Fin which n is between 1 and 3, in the E or Z form, or a mixture of the two isomeric forms, possessing antimitotic, antiproliferative and antivascular properties through inhibition of the polymerization of tubulin into microtubules

Compounds derived from oxindoles and their therapeutic application in cancer treatment

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Paris, France

Marielle Chiron