Freie Universitat Berlin

The University of British Columbia

Freie Universitaet Berlin

Mivenion Gmbh

Epiios Therapeutics Gmbh

Ic Discovery Gmbh

Marie Weinhart

Donald Elliott Brooks

Jayachandran N Kizhakkedathu

Kai Licha

Wolfgang Friess

Rainer Haag

Qiang Wei

Ingo Grunwald

Michael Schirner

Rajesh Shenoi

Florian Paulus

Benjamin Lai

Dominic Groeger

Tobias Becherer

Uwe Schedler

Leixiao Yu

Pia Welker

Laura Elomaa

Kerstin HÖGER

Sarah Hedtrich

The disclosure relates to an amphiphilic block copolymer comprising a first block consisting of a polymeric hydrophilic domain, wherein the polymeric hydrophilic domain consists of a polyglycerol; an optional second block consisting of a hydrophobic domain and a first linker domain, wherein the second block is covalently bound to the first block via the first linker domain, an optional third block consisting of a catechol domain and a second linker domain, wherein the third block is covalently bound to the first block via the second linker domain; and a fourth block consisting of a crosslinking domain and a third linker domain, wherein the fourth block is covalently bound to the first block via the third linker domain, wherein the crosslinking domain comprises a reactive residue enabling a crosslinking between individual molecules of the amphiphilic block copolymer.

Amphiphilic block copolymer and coating arrangement

The invention relates to a linear polyglycerol compound, comprising a backbone of linearly linked glycerol residues. This compound is characterized in that it carries a plurality of substituents in the nature of covalently bound sulfates, wherein a degree of substitution of the backbone is preferably between 30 and 100%. A method of manufacturing the compound as well as uses of this compound and similar compounds are also disclosed.

Anionic linear polyglycerol derivatives, a method for manufacturing and applications

An article, comprising a substrate and a polymer film attached to the substrate is provided, the polymer film comprising a first layer of a first polymer functionalized by a first functionalization compound covalently bound to said first polymer and bearing at least one catecholic group being present on a surface of the first layer. The polymer film is a layered film, a top layer of which is formed by the first layer, the layered film comprising at least one further layer of at least one further polymer functionalized by a further functionalization compound covalently bound to said further polymer and bearing at least one catecholic group being present on a surface of the at least one further layer, wherein an average ratio of catecholic groups per polymer molecule is equal to or less than 1 in case of the first polymer and greater than 1 in case of the further polymer.

Bioinert article and its use

The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.

Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis

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Berlin, Germany

Marie Weinhart