Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Institut Curie

Université Paris-Saclay

UniversitÉ De Paris

Université De Bretagne Occidentale

Univ Paris Xiii Paris-nord Villetaneuse

Centre Hospitalier Regional Universitaire De Brest

Centre National De La Recherche Scientifique-cnrs

Universite Paris Cité

MusÉum National D'histoire Naturelle

Centre Hospitalier RÉgional Et Universitaire De Brest

Marie-Paule Teulade-Fichou

Fabrice Charra

Jean-Louis Mergny

Marc Blondel

Jean-François Riou

Robin Fahraeus

Claire Beauvineau

Oksana Reznichenko

Cécile Voisset

Chrysoula Daskalogianni

Clémence Allain

Céline Fiorini-Debuisschert

Rodrigo Prado-Martins

Rémy Lartia

Alicia Quillevere

Maria José Lista

Anton Granzhan

David Monchaud

Myriam Rouchon Dagois

Chi-hung Nguyen

David Grierson

Aurore Guedin-Beaurepaire

The present invention relates to novel bis-hydrazone derivatives of formula (I): wherein Arand Armay be identical or different and are each independently selected from the group consisting of groups of formula (II) and (III): Yand Zare independently CH or NR, provided that al least one of Yand Zis NRand at least one of Yand Zis CH,and R, R, R, Xand L as defined in the claims, or a hydrate or a solvate thereof. Compositions and kits comprising same are also described. Said bis-hydrazone derivatives of formula (I), compositions and kits are useful as drugs, in particular for treating or preventing cancers associated with the Epstein-Barr Virus.

Hydrazone derivatives for preventing or treating EBV-related cancers

Triphenylamine derivatives useful as fluorophores in biology, in particular for two-photon microscopy; and compositions comprising these derivatives, to the use of these compositions and of the derivatives themselves for labelling biological molecules (or 'biomolecules') such as nucleic acids, oligonucleotides, proteins, polypeptides, plasmids, and the like, for their examination in particular by two-photon microscopy, and to biomolecules labelled with the said derivatives.

Triphenylamine derivatives useful as fluorophores in biology, in particular for two-photon microscopy

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Paris, France

Marie-Paule Teulade-Fichou