Kali-chemie Pharma Gmbh

Laboratoires De Therapeutique Moderne

Marie-Odile Christen

Samuel David

Ulf Preuschoff

Ivan Ban

Insa Hell

Daniel Jasserand

Dominique Biard

Jean-Louis Burgot

Dimitri Yavordios

Patrick Dansette

Daniel Mansuy

Ilse Philippi

Brigitte Noel

Herman Kraehling

Hermann Kraehling

Amor Sassi

The present invention relates to therapeutic compositions based on compounds chosen from the formulae: ##STR1## in which: X is chosen from .dbd.S, .dbd.O, .dbd.SO, .dbd.N--OH, .dbd.N--R.sub.5, .dbd.N--NH--CONH.sub.2, .dbd.N--NH--CSNH.sub.2 and ##STR2## A is chosen from the &gt;C.dbd.N--OH group, a group of formula &gt;C.dbd.N--OR.sub.3, a C.dbd.O group, a group C.dbd.N--R.sub.4 and a CHOH group, and their pharmaceutically acceptable salts. These compositions may be used as free-radical trapping agents.

Therapeutic compositions based on 1,2-dithiole-3-thione derivatives

Pharmacologically active compounds corresponding to the general formula I: ##STR1## wherein m represents 1-4,

Phenyalkylaminoalkyl compounds and pharmaceutical compositions

A method of inhibiting peripheral blood circulation disorders or damage such as hemorrhagic lesions induced by gastrotoxic doses of substances such as alcohol or non-steroid, antiinflammatory medicaments in the gastrointestinal tract of a mammal comprising administering to said mammal an effective peripheral circulation disorder or gastrointestinal damage inhibiting amount of a quaternary N-benzyl-N-{2-[2-((1S,5S)-6,6-dimethylbicyclo[3,1,1]hept-2-yl)-ethoxy]-eth yl}-morpholinium salt, and pharmaceutical compositions comprising a substance having a tendency to induce a peripheral blood circulation disorder or damage such as a hemorrhagic lesion in the stomach and/or intestinal wall of a mammal and an effective peripheral circulation disorder or gastrointestinal damage inhibiting amount of a quaternary N-benzyl-N-{2-[2-((1S,5S)-6,6-dimethylbicyclo[3,1,1]hept-2-yl)-ethoxy]-eth yl}-morpholinium salt.

Gastroprotective pharmaceutical preparations containing

Pharmacologically active compounds corresponding to the formula I ##STR1## in which n represents 2-5,

Alkylaminoalkylamine and ether compounds, processes and intermediates

The use of 5-phenyl-3H-1,2-dithiol-3-thion-S-oxides which are optionally substituted in the phenyl ring as active substances in hepato-protective medicaments and new 5-phenyl-3H-1,2-dithiol-3-thion-S-oxides which are substituted in the phenyl ring are described.

1,2-dithiol-3-thion-S-oxide compounds and pharmaceutical compositions

5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds of the Formula ##STR1## in which R.sub.1 is a straight-chain, branched or cyclic alkyl group with up to 6 carbon atoms, Z is an alkylene chain with 2 to 4 carbon atoms, and 1-phenyl substituent is an optionally substituted phenyl ring, and R.sub.4 is a phenyl or pyridyl group which is optionally substituted and their preparation are described. The compounds have pharmacological, particularly antiallergic, properties.

Antiallergic 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds

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Paris, France

Marie-Odile Christen