Centre National De La Recherche Scientifique

Universitè De Montpellier

Nanomedsyn

University of California

Institut National De La Sante Et De La Recherche Medicale

Université Montpellier 2 Sciences Et Techniques

Ecole Nationale Superieure De Chimie De Montpellier

Université De Montpellier I

Marie Maynadier

Marcel Garcia

Alain Morere

Jean-Olivier Durand

Magali Gary-Bobo

Michael J Sailor

Jean Martinez

Frederique Cunin

Jean Olivier Durand

Khaled El Cheikh

Ilaria Basile

Laurence Raehm

Muriel Amblard

Lubomir Vezenkov

Jean-Francois Hernandez

Afitz Da Silva

Jimenez Chiara Mauriello

Elise Bouffard

Sebastien Richeter

Emilie Secret

Jean-françois Hernandez

Magali Gary-bobo

Sébastien Richeter

Chiara Mauriello Jimenez

Frédérique Cunin

The present invention relates to mesoporous organosilica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.

Mesoporous organosilica nanoparticles, production method thereof and uses of same

The subject matter of the present invention is a compound characterized in that it has the general formula (I): in which P, X, n, A, L and Lare as defined in Claim. The present invention also relates to a process for preparing said compounds (I) and to the use thereof for targeting the cation-independent mannose 6-phosphate receptor (CI-M6PR). The subject matter of the invention is also a conjugate of formula (III): in which P, X, n, A, L and L'are as defined in Claim, and the use thereof: &#x2014;in a method for therapeutic treatment of the human or animal body, in particular chosen from enzyme replacement therapy, photodynamic therapy or cancer treatment, and/or&#x2014;in a method of diagnosis, in particular of diseases or of ailments associated with an increase or with a decrease in CI-M6PR expression. 

Multi-functionalized polysaccharide compounds and use thereof for targeting the cation-independent mannose 6-phosphate receptor

Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (&#x3e;600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.

Functionalized porous silicon nanoparticles and use thereof in photodynamic therapy

The invention relates to the use of oligomers having constrained dipeptide or tripeptide motifs as agents for the vectorization of active ingredients.

Use of constrained peptide mimic oligomers as vectorization agents

Growing community of inventors

Ceyras, France

Marie Maynadier