Centre National De La Recherche Scientifique

Université Pierre Et Marie Curie (Paris 6)

Université Pierre Et Marie Curie

Université De Versailles—saint-Quentin-En-Yvelines

Sorbonne Université

Centre National De La Recherche Scientifique-Cnrs

Marie-Madeleine Giraud-Guille

Clément Sanchez

Clement Sanchez

Cedric Boissiere

Cédric Boissiere

Nadine Nassif

Gervaise Mosser

Frédéric Gobeaux

Yan Wang

Christophe Helary

Francisco Miguel Moreira Martins Fernandes

Anne Pelle

Disclosed is the preparation of injectable collagen suspensions, to the method for preparing the suspensions, and to the uses thereof, particularly for forming dense collagen matrices.

Injectable collagen suspensions, the preparation method thereof, and the uses thereof, particularly for forming dense collagen matrices

A method for preparing a synthetic material having an organic phase and a mineral phase which consists in preparing an initial acidic aqueous solution of collagen which is a precursor for the organic phase (I), and at least one aqueous solution of precursors for the mineral phase (II), and in precipitating the collagen by increasing the pH to a value of at least 7. The method includes the concentration of collagen in the acidic aqueous solution is at least 75 mg/ml and remains constant during said increase in pH. The mineral phase precursors have at least one calcium salt and at least one phosphate salt. The precipitation of the mineral phase (II) is carried out by bringing the mineral phase precursor solution into contact with the organic phase (I), the bringing into contact being carried out before or after the precipitation of the organic phase (I).

Bone substitute, and method for the preparation thereof

Method for preparing a homogeneous collagen-based material by concentration of a collagen solution, includes bringing a collagen solution into contact by way of continuous injection and use of the material for tissue repair.

Dense fibrillar collagen matrices for tissue repair and the preparation method thereof

Growing community of inventors

Paris, France

Marie-Madeleine Giraud-Guille