L'oreal

Marie-Madeleine Cals-Grierson

Pascale Pelletier

Maria Dalko

Yann Mahe

Novel pyrimidine N-oxide compounds and salts thereof, well suited for stimulating the growth of keratin fibers (e.g., the hair or the eyelashes) and/or limiting the loss thereof and/or increasing their density, have the formula (A): in which n is an integer ranging from 2 to 12; Ris a linear or branched, saturated or unsaturated alkyl radical, optionally substituted with a group &#x2014;OR', &#x2014;NR&#x2032;R&#x2033; or &#x2014;COOR&#x2032;, Rhaving from 1 to 20 carbon atoms, or is NR&#x2032;R&#x2033;; Ris hydrogen, &#x2014;NRR, &#x2014;OR, or &#x2014;SR, wherein Rand R, which may be identical or different, are each a linear or branched, saturated or unsaturated alkyl radical, optionally substituted with a group &#x2014;OR&#x2032;, &#x2014;NR&#x2032;R&#x2033; or &#x2014;COOR&#x2032;, Rhaving from 1 to 20 carbon atoms, with the proviso that Rand Rmay form part of a saturated or unsaturated ring member of 4 to 7 atoms, optionally containing at least one hetero atom; and R&#x2032; and R&#x2033;, which may be identical or different, are each hydrogen or a saturated, linear or branched C-Calkyl radical.

Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof

The invention concerns the use of an efficient amount of at least an extract of an least a plant of thespecies in a physiologically acceptable medium, in a composition or for preparing a composition, the extract or composition being designed to inhibit NO-synthase.

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The invention concerns relates to the use of an efficient amount of lipochroman-6, in a physiologically acceptable medium, in a composition or for preparing a composition, the lipochroman-6 or the composition being designed to inhibit NO-synthase.

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Meudon, France

Marie-Madeleine Cals-Grierson