Institut Merieux

Pasteur Merieux Serums & Vaccins

Pasteau Merieux Serums Et Vaccins

Marie-Jose B Quentin-Millet

Francois Arminjon

Bruno Guy

Jean Haensler

Ling Lissolo

Monique Dupuy

Roupen R Donikian

The invention relates to a pharmaceutical composition intended for inducing in a host mammal a protective immune response against an antigen, at a mucosal effector site, which comprises at least two identical or different products each containing an inducing agent for the immune response, selected from the antigen and, provided the antigen is protein in nature, an expression cassette capable of expressing the antigen, for a concomitant or consecutive administration; one of the products being formulated so as to be administered via the nasobuccal route so that the inducing agent is targeted to the inducer site(s) for an immune response in the naso-oropharynx or the salivary glands, the other product being formulated so as to be administered via a suitable mucosal route other than the nasal route, so that the inducing agent is targeted to the inducer site(s) for an immune response at the effector site at which the immune response is sought. Optionally, such a composition can also comprise a third product, identical to or different from the first two, formulated for systemic administration.

Methods for inducing a mucosal immune response

Helicobacter lactoferrin receptor

Vaccine against Neisseria meningitidis infections

A chromatography material comprises a solid support on which is fixed, as a ligan, desialyled gycolprotein selected from desialyled fetuin and desialyled haptoglobin. This material is used to purify protein antigens of bacteria of the Bordetella genus.

Separation of protein antigens of Bordetella bacteria by affinity

A chromatography material comprises a solid support on which is fixed, as a ligand, desialyled gycolprotein selected from desialyled fetuin and desialyled haptoglobin. This material is used to purify protein antigens of bacteria of the Bordetella genus.

Affinity chromatography material for antigens of the bacteria of the

A culture medium composition for bacteria of the Bordetella genus comprises a nutrient medium containing cyclodextrin or a salt thereof in combination with an etherified derivative of D-glucose polymer having a molecular mass at least equal to 2,000. A process for culturing bacteria of the Bordetella genus with such a medium is also disclosed.

Culture medium for bacteria of the bordetella genus containing

A method for the purification, solubilization and/or detoxification of protein antigens of bacteria of the Bordetella genus involves the use of a carbonate buffer having a pH of 8.3 to 11.6. An acellular anti-whooping cough vaccine containing active principles in this carbonate buffer is also disclosed.

Growing community of inventors

Villeurbanne, France

Marie-Jose B Quentin-Millet