Roussel Uclaf

Marie-Helene Kannengiesser

Lucien Nedelec

Claude Dumont

Andre Pierdet

Daniel Frechet

7-AMINO-6,7-DIHYDRO [5H] benzocycloheptenes of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, chlorine, bromine and iodine in 2- or 4- position of the ring when halogen and R is selected from the group consisting of hydrogen and phenyl alkyl of 7 to 10 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressive activity and a process for their preparation and novel intermediates.

7-Amino-6,7-dihydro [5H]benzocycloheptene derivatives

Novel benzazepines of the formula ##STR1## wherein n is 0 or 1 and R and R.sub.1 are individually selected from the group consisting of hydrogen and methyl with the proviso that when R.sub.1 is methyl, R is also methyl and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressive activity and novel intermediates and processes for the preparation of the said compounds.

Novel benzazepines

Novel 7-amino-benzocycloheptenes of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, chlorine, bromine and iodine in the 2- or 4-position when a halogen, Y and Z are hydrogen or together form a double bond, R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and phenyl optionally substituted with fluorine, chlorine, methyl or methoxy, R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and alkenyl of 2 to 5 carbon atoms and R.sub.2 is selected from the group consisting of alkyl of 1 to 5 carbon atoms and alkenyl of 2 to 5 carbon atoms and R.sub.1 and R.sub.2 taken together with the nitrogen atom to which they are attached form a saturated heterocycle of 4 to 6 carbon atoms and optionally containing another hetero-atom and optionally substituted with an alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressive activity and their preparation and novel intermediates.

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Marie-Helene Kannengiesser