Université Libre De Bruxelles

Universitéde Liége

Marie-Hélène Antoine

Bernard Pirotte

Pascal De Tullio

Philippe Lebrun

Stéphane Boverie

Sophie Sebille

The invention relates to novel benzopyran derivatives of formula I, to their method of production, to composition comprising the derivatives and use thereof. wherein:R, R, Rand Rare independently hydrogen, halogen, C-alkyl, C-cycloalkyl, hydroxy, C-alkoxy, C-alkoxy-C-alkyl, nitro, amino, cyano, cyanomethyl, perhalomethyl, C-monoalkyl- or dialkylamino, sulfamoyl, C-alkylthio, C-alkylsulfonyl, C-alkylsulfinyl, formyl, C-alkylcarbonylamino, Rarylthio, Rarylsulfinyl, Rarylsulfonyl, C-alkoxycarbonyl, C-alkoxycarbonyl-C-alkyl, carbamoyl, carbamoylmethyl, C-monoalkyl- or dialkylaminocarbonyl, C-monoalkyl- or dialkylaminothiocarbonyl, ureido, C-monoalkyl- or dialkylaminocarbonylamino, thioureido, C-monoalkyl- or dialkylaminothiocarbonylamino, C-monoalkyl- or dialkylaminosulfonyl, carboxy, carboxy-C-alkyl, acyl, Raryl, Raryl-C-alkyl, Raryloxy;Rand Rare each independently hydrogen, C-alkyl or, Rand Rtaken together with the carbon atom to which they are attached form a 3- to 6-membered carbocyclic ring;Ris 2-, 3- or 4-pyridyl optionally mono- or polysubstituted by R;Ris 2- or 3-thienyl optionally mono- or polysubstituted substituted by RorRis phenyl optionally mono- or polysubstituted by Rwith the exception of or Rrepresenting CH;Ris hydrogen, halogen, C-alkyl, C-cycloalkyl, hydroxy, C-alkoxy, nitro, amino, cyano, cyanomethyl, perhalomethyl;or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture or any polymorphic and tautomeric form.

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Brussels, Belgium

Marie-Hélène Antoine