Sanofi-Aventis

Sanofi

Marie-Francoise Bordes

Alain Badorc

Francoise Bono

Jean-Marc Herbert

Nathalie Guillo

Chantal Alcouffe

Daniel Frehel

Jean-Michel Foidart

Agnes Noel

Jean-Marie Rakic

The invention concerns compounds of formula I, a method for preparing said compounds, pharmaceutical compositions containing same and the therapeutic uses thereof. 

Imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same

The present invention thus relates to the use of 1,2,3-substituted indolizine derivatives in the preparation of medicaments of use in the treatment of diseases related to pathological choroidal angiogenesis, which derivatives correspond to the following general formula (I): 

Use of FGF inhibiting substituted 1,2,3 indolizine derivatives in the preparation of medicaments which can be used to treat diseases linked to pathological choroidal angiogenesis

Imidazo[1,5-a] pyridine derivatives, method for preparing same and pharmaceutical compositions containing same

The present invention relates to novel 1,2,3-substituted indolizine derivative which are inhibitors of fibroblast growth factors, to methods or preparing such derivatives, to pharmaceutical compositions comprising such derivatives, and to methods of treatment comprising such derivatives.

1,2,3-substituted indolizine derivatives, inhibitors of FGFs, method for preparing them and pharmaceutical compositions containing them

The invention is directed to a compound of formula I, wherein R, R, R, Rand Rare as defined herein, or a pharmaceutically acceptable salt thereof, and its pharmaceutically composition, preparation and uses as an inhibitor of FGFs (fibroblast growth factors).

Substituted indolizine 1,2,3,6,7,8 derivatives, FGFs inhibitors, a method for the preparation thereof and pharmaceutical compositions containing said derivatives

Compounds of formula I or salts thereof: in which

1,2,3-substituted indolizine derivatives, inhibitors of fgfs, method for making same and pharmaceutical compositions containing same

The invention relates to compounds of formula ##STR1## in which R.sub.1 is selected from the groups R.sub.3 and OR.sub.3, R is selected from H and a group CHR.sub.2 R', in which R.sub.2 is selected from H, alkyl, carboxy and carboxamido and R', is H, alkyl or phenyl, Z represents S or O; and m and n, which may be identical or different, equal 1 or 2, and their N-oxides, salts and quaternary ammonium derivatives. The invention also relates to the process for preparing these compounds, as well as to pharmaceutical compositions containing them.

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Labarthe sur Leze, France

Marie-Francoise Bordes