Rhone-Poulenc Rorer S.a.

Rhone-Poulenc Sante

Pharmindustrie

Pharmuka Laboratoires

Rhone-Pouelnc Rorer S.a.

Marie-Christine Dubroeucq

Christian L Renault

Franco Manfre

Gerard R Le Fur

Marc Capet

Claude Guyon

Michel Barreau

Gilles Dutruc-Rosset

Michel Cheve

Jesus Benavides

Michel Tabart

Claude Moutonnier

Jean-Francois Peyronel

Jean-Paul Martin

Alain Truchon

Claude G Gueremy

Jean E Rataud

Jean-Marc Paris

Jean Leboul

Andrees Bohme

Assunta Imperato

Gerard Helynck

Francois-Frederic Clerc

Jacques Mizoule

Jean-Jacques Barieux

Francois Rocquet

Walter Fratta

Gerard LeFur

Heterocyclic carboxamide compounds effective in the treatment of drug

Peptide antagonists of neurotensin

Pyrrolidine derivatives for the treatment of cholecystokinine and

N-acylpyrrolidines and medicaments for the treatment or prevention of

Thiazolidine derivatives, their preparation and the medicaments

The present invention relates to a new isoindolinone derivative of formula: ##STR1## in racemic form or in the form of its enantiomers, as well as its salts, its preparation and the pharmaceutical compositions which contain it.

Isoindolinone derivative, preparation thereof and pharmaceutical

Ureidoacetamide derivatives, their preparation and the medicaments

Pyrrolidine and thiazolidine derivatives, their preparation and drugs

Thiazolidine derivatives, preparation thereof and drugs containing samem

N-acyl pyrrolidines and drugs for the treatment or prevention of

Isoindolinone derivative, preparation thereof, and pharmaceutical

New isoindolone derivatives of general formula (I) are ##STR1## disclosed in which the radicals R represent hydrogen atoms or, together, form a bond, the symbol R' represents a hydrogen atom or a readily removable radical and the symbols R' are identical and represent phenyl radicals which can be substituted with a halogen atom or a methyl radical at the ortho or meta position, in the (3aR, 7aR) form or in the form of a mixture of the (3aRS, 7aRS) forms, as well as their salts. These derivatives are useful as intermediates for the preparation of therapeutically active products.

Isoindolone derivatives

This invention relates to isoindolone derivatives of general formula (I) in which the radicals R are hydrogen atoms or together form a bond, the symbols R' are phenyl radicals which can be substituted by a halogen atom or a methyl radical in position 2 or 3, X is an oxygen or sulphur atom or a radical N--R.sub.3, R.sub.3 being H, optionally substituted alkyl or dialkylamino, R.sub.1 is optionally substituted phenyl or cyclohexadienyl, naphthyl or a heterocycle and R.sub.2 is H, halogen, OH, alkyl, amionoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, acyloxy, carboxyl, optionally substituted alkoxycarbonyl, benzyloxycarbonyl, amino or acylamino, in their (3aR,7aR) forms or in the (3aRS,7aRS) form or their mixtures, and if appropriate their salts where such exist, and their preparation. The new derivatives according to the invention are particularly valuable as antagonists of substance P. ##STR1##

Isoindolone derivatives, their preparation and the pharmaceutical

Quinoline derivatives of formula: ##STR1## in which either R.sub.1 denotes trifluoromethyl, R.sub.2 and R.sub.3 form, together with the nitrogen atom to which they are attached, morpholino and R.sub.4 denotes a 4-methylphenyl, 4-chlorophenyl, 2-, 3- or 4-fluorophenyl, 4-methoxyphenyl, 4-methyl-3-fluorophenyl, 2,4-difluorophenyl or 4-aminophenyl,

Quinolyloxyacetamides

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Enghein les Bains, France

Marie-Christine Dubroeucq