Spofa United Pharmaceutical Works

Spofa, United Pharmeceutical Works

Spofa, Pharmaceutical Works

Marie Auskova

Miroslav Semonsky

Miroslav Seda

Karel Rezabek

Antonin Cerny

Jiri Krepelka

Bohumil Sevcik

Rudolf Kotva

Josef Kral

Viktor Zikan

Marie Krajcrova

Karel Rezabeck

Milos Beran

A procedure is described for the preparation of a novel group of alkyl cyanomethyl ergoline-I derivatives and pharmaceutically acceptable salts thereof. The compounds are D-6-alkyl-8-cyanomethylergoline-I derivatives of the formula ##STR1## wherein R is an alkyl group of 2-4 carbon atoms.

Alkyl cyanomethyl ergoline-I derivatives and salts thereof, and methods

A process is described for the preparation of novel 6 substituted derivatives of D-8-ergolin-I-ylacetamide and the pharmaceutically acceptable addition salts thereof. The described composition evidences superior antilactation and antinidation characteristics as compared with prior art compounds.

D-6-allyl-8-ergol-I-ylacetamide

Novel N.beta.-substituted 8-.beta.-aminoethylergolin-I derivatives and the acid addition salts thereof are disclosed. The described compositions are prepared by either reductive alkylation or selective reduction of corresponding derivatives containing carbonyl groups.

N.beta.-substituted 8-.beta.-aminoethylergolin-I derivatives and their

A new compound, N-(D-6-methyl-8-isoergoline-I-yl)-N', N'-diethylurea, processes for preparation and purification thereof, and therapeutic uses therefor in mammals.

N-(D-6-methyl-8-isoergoline-I-yl)-N',N'-diethylurea

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Prague, Czechia

Marie Auskova