Alk-abello A/s

Biomay Ag

Marianne Van Hage

Rudolf Valenta

Peter Valent

Susanne Vrtala

Hans Grönlund

Kerstin Westritschnig

Margarete Focke-Tejkl

Birgit Linhart

Susanne Spitzauer

Ines Swoboda

Theresia Popow-Kraupp

Renate Reininger

Johanna Tinhofer

Dander from the domestic cat () is one of the most common causes of IgE mediated allergy. The present invention relates to a recombinant folded Fel d 1 with molecular and biological properties similar to the natural counterpart and specifically a synthetic gene coding for a direct fusion of Fel d 1 chain 2 N-terminally to chain 1.expression resulted in a non-covalently associated homodimer with an apparent molecular weight of 30 kDa defined by size exclusion chromatography, each 19177 Da subunit displayed a disulfide pattern identical to that found in the natural Fel d 1, and having identical fold of natural and recombinant Fel d 1. The, recombinant Fel d 1 provides for diagnosis and allergen specific immunotherapy of cat allergy.

Recombinant allergen

The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.

Vaccine carrier

Growing community of inventors

Bromma, Sweden

Marianne Van Hage