Hoffmann-la Roche Inc.

Marianne Rouge

Hans Peter Wessel

Gerard Schmid

Thomas B Tschopp

Hans P Marki

Niggi Iberg

Michael Pech

Jurgen Fingerle

Alexander Chucholowski

Rita Muller

Milan R Uskokovic

Giacomo Pizzolato

Pasquale N Confalone

Compounds of the formula ##STR1## wherein n.sup.1 -n.sup.9 are each independently 0 or 1;

Sulfuric acid esters of sugar alcohols

Compounds of formulas ##STR1## wherein, B is lower alkylene or an optionally substituted aromatic ring system;

Sulfuric acid esters of amino sugars

The present invention is concerned with novel sulfuric acid esters of sugar alcohols and sugar alcohol-like compounds of the formula ##STR1## Also described are methods for the treatment and/or prophylaxis of arteriosclerotic changes in the vascular wall as well as a process for the manufacture of the compounds of formula I and their salts.

Thiophene derivatives having utility as blood lipid lowering agents and as antiobesity agents are disclosed.

Novel thiophene derivatives

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Basel, Switzerland

Marianne Rouge