Janssen Pharmaceutica Nv

Janssen Biotech, Inc.

Marianne Borgers

Marc Mercken

Kristof Van Kolen

Thomas J Malia

Jinquan Luo

John Wheeler

Rupesh Nanjunda

Linda Barone

Eilyn R Lacy

Marc Maria Pierre Pelagie Vandermeeren

Bianca Julia J Van Broeck

Monoclonal anti-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies. The antibodies of the invention may also be used to quantify tau in biological samples.

Anti-PHF-tau antibodies and uses thereof

Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.

The present invention provides monoclonal antibodies which specifically recognize the shorter A&#x3b2; peptides obtained after cleavage of the APP protein mediated by &#x3b3;-secretase, i.e. the A&#x3b2;-peptide fragments A&#x3b2;1-37, A&#x3b2;3-37, A&#x3b2;3p-37, A&#x3b2;1-37 and A&#x3b2;11p-37, and other like fragments ending at the 37amino acid of APP, hereinafter also referred to as the A&#x3b2;x-37 peptides. It further provides hybridoma cells producing the monoclonal antibodies as well as methods for producing the antibodies and the hybridoma cells; and an immunoassay for an A&#x3b2;x-37 peptide by a competitive method or a sandwich method using the antibody of the present invention; and methods for measuring the level of A&#x3b2;x-37 peptides in a sample, such as a biological sample.

Monoclonal antibodies specific for beta-amyloid x-37 and uses thereof

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Balen, Belgium

Marianne Borgers