Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Marianna Kovacs

Gabor Kovacs

Sandor Virag

Istvan Stadler

Istvan Tomoskozi

Jozsef Ivanics

Geza Galambos

Gyorgy Dorman

Peter Gyory

Karoly Kanay

Peter Kormoczky

Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation, R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or --C.dbd.C--, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.

Selective biologically active 7-oxo-prostacyclin derivatives and

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Budapest, Hungary

Marianna Kovacs