Breye Therapeutics Aps

Axxam S.p.a.

Mariangela Sodano

Paolo Pevarello

Russell Thomas

Valentina Cusano

Domenica Torino

Rocco Vitalone

Elda Severi

Oleksii Artamonov

Ali Munaim Yousif

Francesco Piscitelli

Disclosed are compounds of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions containing them, and to a process for the preparation of the compounds: Ris independently selected from hydrogen atom, amine group, monocyclic or bicyclic aliphatic, aromatic, heteroaliphatic or heteroaromatic ring. Ris independently selected from monocyclic or bicylic aliphatic, heteroaliphatic, aromatic or heteroaromatic ring, C-Calkyl, alkenyl or alkynyl chain. n is 1 or 2; preferably n is 1. m is 0, 1 or 2; preferably m is 0. Rand Rcan be, independently, &#x2014;H, &#x2014;F, C-Calkyl, &#x2014;OH, &#x2014;OC-Calkyl; preferably they are both &#x2014;H. X is O or S. Ris &#x2014;H or &#x2014;CHoptionally substituted by one or more fluorine atoms; preferably Ris hydrogen. The compounds can be used in the treatment of conditions or diseases mediated by P2X7 receptor.

Heterocyclic P2X7 antagonists

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Bresso, Italy

Mariangela Sodano