Ferro Dynamics, Inc.

University of Texas System

Ferrosensor, Inc.

Regen Therapeutics Plc

Vitaerx Pharmaceutical, Inc.

Ferradynamics, Inc

Marian L Kruzel

Paul D Gollnick

Tomasz Kurecki

Darrell J Doyle

Jerzy Alexander Georgiades

Kurt S Myers

Thomas K Hughes, Jr

G John Stanton

Istvan Boldogh

Jaroslaw Aronowski

Michal Zimecki

Antoni Polanowski

Gilbert A Castro

Tadeusz Wilusz

Tadeusz Kruzel

Methods and compositions are provided for the treatment of a patient with intracranial hemorrhage (ICH). Methods include the use of the products of recombinant constructs such as those that contain lactoferrin, as well as fusion protein constructs of lactoferrin and Fc domain for IgG.

Methods and compositions for treatment of symptoms associated with intracranial hemorrhage

The invention relates to the purification of peptides from colostrum. The method involves the addition of an alcohol such as methanol or ethanol to the mixture in order to form an alcohol phase rich in the peptides, and a precipitate. The peptide-rich alcohol phase is subsequently recovered and subjected to further fractionation. The invention is particularly useful in the purification of colostrinin from colostrum.

Purification of peptides from colostrum

The method of the present invention provides a novel use of lactoferrin to modulate the molecular events during development of age-related disorders in humans. More specifically, the present invention is directed to the use of lactoferrin to treat or prevent autoimmune, neurodegenerative and immune hypersensitivity disorders, and its use for the manufacture of a medicament for the treatment or prevention of such conditions.

Lactoferrin for age related disorders in humans

The present invention provides methods that utilize compositions containing colostrinin, a constituent peptide thereof, an active analog thereof, and combinations thereof, as modulators of intracellular signaling molecules, for example.

Use of colostrinin, constituent peptides thereof, and analogs thereof as modulators of intracellular signaling molecules

The method of the present invention provides a novel use of the iron binding protein lactoferrin to prevent or treat the insult-induced metabolic imbalance in humans and other animals. More particularly, the present invention is the use of lactoferrin for the manufacture of a medicament for the treatment of the metabolic hypo- or hyperactivity in the gut.

Method for treating aseptic SIRS in humans and other animals

Disclosed is human lactoferrin clone, its method of production and purification.

Human lactoferrin

Disclosed is human lactoferrin expressed using recombinant DNA, its method of production and purification.

Cloning, expression, and uses of human lactoferrin

The present invention is directed to iron sensors. Immobilized in close proximity of the potential or pH measuring surface of a proton sensing device, minute quantities of an iron chelator such as siderophores or transferring cause detectable variation of the potential or pH upon the binding of iron. The sensing devices for measuring this change in potential or pH include the iron chelator-modified ion-selective field effect transistors (IC-ISFET) and/or pH indicator papers of the present invention.

Iron detecting sensors

A simple, cost effective assay of iron is accomplished by using lactoferrin as part of a biosensor to detect iron in a sample. The lactoferrin releases protons when the iron is sequestered by the lactoferrin and the change in potential caused by the release of protons is measured by a potentiometer or pH sensing device. The sensing devices include the ion-selective or ion sensitive field effect transistors (ISFET), a potentiometric device or the pH indicator papers.

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Houston, TX, United States of America

Marian L Kruzel