Pacific Biosciences of California, Inc.

Mariam Iftikhar

Pinar Iyidogan

Bridget Kidd

Lewis Churchfield

Provided herein are engineered DNA polymerases comprising modifications improving accuracy and processivity of the polymerase including modifications in the Motif A region, optionally, along with additional modifications in the palm and/or exonuclease domains of the polymerase. Also provided are nucleic acids encoding the engineered DNA polymerases comprising modifications in motif A of the polymerase, optionally, with additional modifications. Methods, vectors, kits, and compositions comprising the nucleic acids and compositions, methods and kits comprising the engineered polymerases are also provided.

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San Diego, CA, United States of America

Mariam Iftikhar