The Texas A&M University System

Rensselaer Polytechnic Institute

Mariah S Hahn

Magnus A Hook

Elizabeth L Cosgriff-Hernandez

Neungseon Seo

Brooke Hageman Russell

Melissa A Grunlan

Xuejun Xu

Marvin Xuejun Xu

Jose J Rivera

Mary Beth Monroe

William B Saunders

Mary Beth Browning

Joshua Erndt-Marino

Elizabeth M Cosgriff-Hernandez

The present disclosure provides synthetic collagen and methods of making and using synthetic collagen that include a synthetic collagen that facilitates wound closure comprising an isolated and purified triple helical backbone protein that facilitates wound closure comprising one or more alteration in a triple helical backbone protein sequence, that stabilize the isolated and purified triple helical backbone protein and does not disrupt an additional collagen ligand interaction; and one or more integrin binding motifs, wherein the isolated and purified triple helical backbone protein facilitates wound closure.

Designer collagens and use thereof

Resolution of a pathological condition is promoted via the application, e.g., via injection, of a potassium osmolyte such as hyperosmolar potassium gluconate, potassium aspartate, another potassium-based salt, or combinations thereof to the condition site. The application of the potassium osmolyte increases the extracellular concentration of potassium ions, reducing the membrane potential of the cells at the condition site and including immune cell quiescence. As a result, the inflammatory response in the patient to the pathological condition is reduced or eliminated. Reducing the inflammatory response is useful in treatment of myriad conditions including arthritis, auto-immune conditions, inflammatory disorders, neurodegenerative disorders, neurodevelopmental disorders, tissue breakdown, etc.

Method of treatment via intra-articular application of potassium

The present invention is directed to a unique technology for preparing a growth-factor free, cylindrical, hydrogel implant that has multiple (three or more) longitudinal hydrogel zones with varying chemical and physical properties. The implant may be wholly made of hydrogels or the hydrogels may be associated with cells, such as mesenchymal stem cells (MSCs).

Implant-based repair of osteochondral defects

The present invention identified a recombinant synthetic collagen containing a triple helical backbone protein produced in a prokaryotic expression system where the protein contains at least one 'inserted' biologically active sequence(s).

Growing community of inventors

College Station, TX, United States of America

Mariah S Hahn