Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag

Mária Vajjon

Tibor Mezei

József Barkóczy

Balázs Volk

Márta Porcs-Makkay

Gyula Lukács

Enikó Molnár

János Szulágyi

Enikö Molnár

Jószef Barkóczy

The invention relates to a process for the preparation of cyclopropyl benzyl ketone compounds of formula (II) wherein Rrepresents fluorine or chlorine atom or Calkoxy group, by the reaction of a Grignard reagent, obtained from the reaction of compound of formula (V), wherein X represents chlorine or fluorine atom, with the compound of formula (IV), wherein Rrepresents Calkyl group, having a straight or branched chain. The process can be applied preferably on industrial scale. Compound of formula (II), wherein R represents a fluorine atom in position 2 is an intermediate of the preparation process of prasugrel, which is a platelet inhibitor used in the therapy. 

Process for the preparation of pharmaceutical intermediates

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Budapest, Hungary

Mária Vajjon