Celmed Oncology (usa), Inc.

Biotechnology Research and Development Corporation

Maria V Sergeeva

Venkata Ramana Doppalapudi

Jonathan S Dordick

Carlo Ballatore

Scott Joel Novick

Ping Wang

This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g.,and. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.

Peptide deformylase activated prodrugs

The invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula:

A method of preparing a polymer-protein composite based upon placing a protein in solution in an organic phase via the ion-pairing of the protein with a surfactant. The polymer-protein composites are useful, for example, as highly active and stable catalysts, in for example, paints and coatings, as well as in medical application.

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San Diego, CA, United States of America

Maria V Sergeeva