Renaltech International, LLC

Other

Cytosorbents Corporation

Purolite International, Ltd.

Maria Tsyurupa

Vadim Davankov

Ludmila Pavlova

James Edward Winchester

James A Brady

Frank M Norris

Peter J Quartararo, Jr

Jamie A Salsberg

Dzidra Tur

Dzirda Tur

Vedirn Davankov

Ludmilla Pavlova

Ludmia Pavlova

D R Tur

Peter J Quartararo

James F Winchester

Vadim Vdavankov

Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of pro-inflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators.

Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood products

Methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood

The present invention is directed to a method of separating electrolytes by size exclusion chromatography using neutral microporous sorbent materials. Two types of sorbents have shown to be most promising: microporous non-functionalized hypercrosslinked polystyrene materials with a pore size comparable to diameters of hydrated electrolyte ions, and microporous activated carbons prepared by pyrolysis of hypercrosslinked polystyrene sorbent beads. In this method, a column comprising hypercrosslinked polystyrene sorbent beads is loaded with a solution of electrolytes, and then eluted with water. Electrolytes with the largest ions elute first, and those with the smallest ions elute last. Selectivity of separation rises with the concentration of the mixture to be separated. With concentrated initial mixtures, concentration of separated components exceeds their concentration in the initial mixture.

Method for separating electrolytes

Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood, generated as a result of extracorporeal blood processing

Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood

A method of purification of physiological liquids of organism has the step of passing a physiological liquid through a material which has a size, a shape, and a structure selected so as to remove toxic compounds from the physiological liquid and is composed of a partially chloromethylated porous highly crosslinked styrene or divinylbenzene copolymer which initially have surface exposed chloromethyl groups in which thereafter chlorine is replaced with an element which forms different surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than that of the chloromethyl group.

Method of and material for purification of physical liquids of organism, and method of producing the material

A beaded polymeric adsorbent has a core part; a shell part arranged around the core part, with one of the parts having a lipophilic property and another of the parts having a hydrophilic property, and is produced by preparing an organic phase composed of water insoluble monounsaturated and poly unsaturated comonomers; preparing an aqueous phase composed of a mixture of water soluble monounsaturated and polyunsaturated comonomers; forming a dispersion of the organic phase and the aqueous phase in a single vessel; and creating conditions for first polymerizing of one of the phases which forms the core part and thereafter polymerizing the other of the phases which forms the shell part.

Method of making biocompatible polymeric adsorbing material for purification of physiological fluids of organism

Disclosed is a method for producing material for purification of physiological liquids of organism. A material has a size, shape and structure selected so as to remove toxic compounds in the molecular range of 300 to 3000 Dalton, and the material is produced from a porous hydrophobic divinylbenzne copolymer, which initially has surface exposed vinyl groups, in which thereafter the vinyl groups are chemically modified so as to form different surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than those of the vinyl groups.

Method of producing material for purification of physiological liquids of organism

Method of purification of physiological liquids of organism

Purification of physiological liquids of organism is performed by passing a physiological liquid with toxicants removed from a patient through a material which has a size a shape, and a structure selected so as to remove toxic compounds in the molecular range of 300 to 30000 Dalton from the physiological liquid and which is composed of a porous hydrophobic divinylbenzene copolymer which initially has surface exposed vinyl groups in which thereafter the vinyl groups are chemically modified so as to form different surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than those of the vinyl groups.

Material for purification of physiological liquids of organism

A method of producing a material for purification of physiological liquids of organism has the steps of providing a polymer which has a size, a shape, and a structure selected so as to remove toxic compounds from the physiological liquids, chemically modifying a surface of the polymer so as to provide hydrophilicity and biocompatibility, and performing the modification in a medium with a content of organic substance which is efficient for preventing endotoxins contamination of the polymer.

Method of producing material for purification of physiological liquids

A method of purification of physiological liquids of organism has the step of passing a physiological liquid through a material which has a size, a shape, and a structure selected so as to remove toxic compounds from the physiological liquid and is composed of a partially chloromethylated porous highly crosslinked styrene or divinylbenzene copolymerwhich initially have surface exposed chloromethyl groups in which thereafter chlorine is replaced with an element which forms different surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than that of the chloromethyl group.

Method of and material for purification of physiological liquids of

For purification of physiological liquids of organism has the step of passing a physiological liquid is passed through a material which has a size, a shape, and a structure selected so as to remove toxic compounds from the physiological liquid and is produced from a partially chloromethylated porous highly crosslinked styrene or divinylbenzene copolymer which initially have surface exposed chloromethyl groups and in which thereafter chlorine is replaced with an element which forms different surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than that of the chloromethyl group.

Growing community of inventors

Moscow, Russia

Maria Tsyurupa