Rijksuniversiteit Leiden

Maria Theodora Van Den Barselaar

Petrus Hendricus Nibbering

Pieter Sicco Hiemstra

Rolf Ide Johannes Feitsma

Ernest Karel Jacob Pauwels

The invention relates to the use of ubiquicidine or optionally modified peptide fragments derived therefrom for the preparation of a drug for the treatment, diagnostics or prophylaxis of infections in humans and animals. A peptide fragment derived from ubiquicidine comprises for instance a preferably continuous series of at least 3, preferably at least 7-13 amino acids from the amino acid sequence of ubiquicidine; KVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPN ANS (SEQ ID NO: 1). Hybrid molecules comprise for instance a cationic peptide with an antimicrobial action and/or a peptide fragment of ubiquicidine and/or a derivative thereof and one or more effector molecules.

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Wassenaar, Netherlands

Maria Theodora Van Den Barselaar