Merck + Co., Inc.

Maria T Matas

Otto D Hensens

Jerrold M Liesch

Janet C Onishi

George M Garrity

Robert A Giacobbe

Henry Joshua

Sagrario M Del Val

Isabel Martin

Dan A Ostlind

Michael D Greenspan

Walter Rozdilsky

James A Milligan

Sagrario Moohales Del Val

Luis Punsola

Paraherquamide and dihydroparaherquamide, known compounds, are disclosed as having antiparasitic activity. The compounds are fungal metabolites isolated from the known fungus Penicillium paraherquei, and from a newly isolated strain of Penicillium charlesii. Compositions including paraherquamide and dihydroparaherquamide as the active ingredient thereof for antiparasitic uses against endo and ecto parasites are also disclosed, as well as processes for the preparation of paraherquamide from the newly isolated fungus.

Paraherquamide and dihydroparaherquamide as antihelminthic agents

Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity. ##STR1##

Novel HMG-CoA synthase inhibitors

Growing community of inventors

Madrid, Spain

Maria T Matas