Merck + Co., Inc.

Maria T Diez

Fernando Pelaez

Gerald F Bills

Deborah L Zink

Francisca Vicente

Robert A Giacobbe

Sandra A Morris

Otto D Hensens

Jerrold M Liesch

Janet C Onishi

Robert E Schwartz

John R Thompson

James E Curotto

Angela Basilio

Angeles Cabello

Sarah J Dreikorn

Isabel Martin

Mary N Omstead

Maria S Meinz

Stanley L Streicher

Rosalind G Jenkins

Bruce W Burgess

Isabella Martin

Seok H Lee

Leeyuan Huang

Anne W Dombrowski

Michael A Goetz

Suzanne M Mandala

Guy H Harris

Yu L Kong

Jon David Polishook

E Tracy Jones

Rosemary A Thornton

Gregory L Helms

Hans E Huber

Wendy S Horn

Mark Rattray

Denis R Patrick

Siobhan Stevens-Miles

Leeyan Huang

Wendy H Clapp-Shapiro

M Dolores Vilella Amils

Marina Mojena Sanchez

Annie Z Zhao

Julian Gorrochategui

Barnali Pramanik

A compound represented by the formula I is disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof. The compound has inhibitory activity against the oncoprotein Raf. Also included are pharmaceutical compositions, methods of treating cancer, cultures of the producing fungal microorganism and methods of fermentative production of the compound.

Bis-aryl ethers, compositions containing such compounds and methods of

There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.

Antifungal agent from sporomiella minimoides

There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.

Antifungal agents

Antifungal agent obtained from hormonema

Antifungal agent

There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.

Antifungal agent produced by arthrinium arundinis  ATCC 74359

A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.

Antifungal compound and compositions containing the compound

Substituted hexahydrobenzopyran derivatives of the Formulae A, B, or C are useful as angiotensin II antagonists: ##STR1##

Substituted hexahydrobenzopyran derivatives as angiotensin II antagonists

This invention relates to strains of the species Curvularia lunata isolated from tree bark and useful in a fermentation process to form compounds of formula (I): ##STR1##

Processes for preparing novel squalene synthetase inhibitors

Squalene synthetase inhibitors and processes therefrom

Growing community of inventors

Madrid, Spain

Maria T Diez