Merck + Co., Inc.

Maria S Meinz

Deborah L Zink

Gerald F Bills

Janet C Onishi

Jerrold M Liesch

Robert E Schwartz

Fernando Pelaez

Robert A Giacobbe

Maria T Diez

Francisca Vicente

Angeles Cabello

Isabella Martin

Sheo B Singh

Russell B Lingham

Leeyuan Huang

Anne W Dombrowski

Keith C Silverman

John R Thompson

Guy H Harris

James E Curotto

Claude Dufresne

Jon David Polishook

Yu L Kong

Sandra A Morris

Wendy S Horn

Stanley L Streicher

Myra B Kurtz

Wendy H Clapp

Josep Guarro

Marie Williams

Sarah J Driekorn

There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.

Antifungal agent obtained from hormonema

There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.

Antifungal agent produced by arthrinium arundinis  ATCC 74359

There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.

Antifungal agents

This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).

Cholesterol-lowering agents

Growing community of inventors

Fair Haven, NJ, United States of America

Maria S Meinz