Almirall, S.a.

Almirall Prodesfarma Ag

Almirall Prodesfarma S.a.

Almirall Ag

Maria Prat Quiñones

Maria Antonia Buil Albero

Maria Dolors Fernandez Forner

Carlos Puig Duran

Dolors Fernandez Forner

Francesc Carrera Carrera

Juan Antonio Perez Andres

Francesca Pajuelo Lorenzo

Montserrat Julia Jane

Jose Aiguade Bosch

Silvia Gual Roig

Victor Giulio Matassa

Laia Sole Feu

María Antonia Buil Albero

Oriol Llera Soldevila

The present invention relates to novel compounds having &#x3b2;2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

Bicyclic derivatives having &#x3b2;2 adrenergic agonist and M3 muscarinic antagonist activities

A compound according to formula (I) wherein:

Quinuclidine derivatives and their use as muscarinic M3 receptor ligands

The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a dicarboxylic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.

Salts of 2-amino-1-hydroxyethyl-8-hydroxyquinolin-2(1H)-one derivatives having both muscarinic receptor antagonist and &#x3b2;2 adrenergic receptor agonist activities

The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a hydroxycarboxylic acid, a sulfonic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.

Salts of 2-amino-1-hydroxyethyl-8-hydroxyquinolin-2(1H)-one derivatives having both &#x3b2;2 adrenergic receptor agonist and M3 muscarinic receptor antagonist activities

The present disclosure relates to 4-(2-amino-1-hydroxyethyl)phenol derivatives of formula (I) as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the &#x3b2;2 adrenergic receptor.

Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the &#x3b2;2 adrenergic receptors

The invention provides 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide in powder inhalant form, and methods of using it for treatment of respiratory disorders.

Quinuclidine derivatives and medicinal compositions containing the same

The invention provides 3-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2] octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, in association with steroids.

A compound which is a carbamate of formula: wherein R1 represents R2 represents a benzyl, phenethyl, furan-2-ylmethyl, furan-3-ylmethyl, thiophen-2-ylmethyl or thiophen-3-ylmethyl group or a straight or branched alkyl group having 3 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, or a cycloalkyl group of 3 to 6 carbon atoms; p is 1 or 2 and the substitution in the azoniabicyclic ring may be in the 2, 3 or 4 position including all possible configurations of the asymmetric carbons; or a pharmaceutically acceptable salt thereof. The pharmaceutically acceptable salt may be of formula: 

Quinuclidine carbamate derivatives and their use as M3 antagonists

The invention provides 3 (R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1 -azoniabicyclo[2.2.2]octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, in association with phosphodiesterase 4 inhibitors.

The invention provides 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, in association with steroids.

Compounds of the formulawherein: {circle around (C)} is phenyl, Cto Cheteroaromatic, naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl or biphenyl;

The invention provides 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2] octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, alone or in combination with other bronchodilatory compounds.

Growing community of inventors

Barcelona, Spain

Maria Prat Quiñones