Sigma-Tau Industrie Farmaceutiche Riunite S.p.a.

Maria Pia Zappavigna

Patrizia Ferrari

Alberto Cerri

Giuseppe Bianchi

Giulio Carzana

Leonardo Banfi

Mara Ferrandi

Marco Torri

Rosamaria Micheletti

Luisa Quadri

Silvia Armaroli

Simona Sputore

Rosamaria Michaeletti

Barbara Moro

Maco Torri

Giuseppe Giacalone

Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na, K-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms. 

Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

New aminoalkoxyimino derivatives at position 3 of substituted B-homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.

Amino derivatives of beta-homoandrostanes and beta-heteroandrostanes

Novel 17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl steroids of the general formula (I) ##STR1## where A, R.sup.1 and R.sup.2 are defined in the specification are disclosed. The compounds have cardiovascular activity. Pharmaceutical compositions containing compounds of formula (I) are also disclosed for the treatment of heart failure and hypertension.

17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl

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Magenta, Italy

Maria Pia Zappavigna