Wyeth

Maria Papamichelakis

Silvio Iera

Arthur G Mohan

John Potoski

Christopher Demerson

Wayne G McMahon

Jacqueline F Lunetta

Michael F MacEwan

Warren Chew

Antonia Nikitenko

Youchu Wang

This invention is directed to methods of preparing 4-substituted quinoline compounds as intermediates in the manufacture of receptor tyrosine kinase inhibitors and intermediate compounds used in the methods thereof, wherein the 4-substituted quinoline compound has the following general formula (I): 

Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof

The present invention provides a new process and intermediates for the production of antiviral compound 4',4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2&#x2032;-disulfonic acid and its pharmaceutically acceptable salts.

Preparation and purification of antiviral disulfonic acid disodium salt

The present invention provides a new process and intermediates for the production of antiviral compound 4&prime;,4-bis-&lcub;4,6-bis-&lsqb;3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino&rsqb;-&lsqb;1,3,5&rsqb;triazin-2-ylamino&rcub;-biphenyl-2,2&prime;-disulfonic acid and its pharmaceutically acceptable salts.

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Montreal, Canada

Maria Papamichelakis