Duke University

The Brigham and Women's Hospital, Inc.

Maria Mirotsou

Victor J Dzau

Tilanthi Jayawardena

A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.

Direct reprogramming of cells to cardiac myocyte fate

A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.

Inhibition of histone methyltransferase for cardiac reprogramming

A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death and/or tissue injury associated with ischemic conditions.

Method of reducing cell death by administering a paracrine factor derived from a mesenchymal stem cell

A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.

Method of reducing cell death by administering a nucleic acid encoding a paracrine factor of a mesenchymal stem cell

Method of reducing cell death by administering a paracrine factor of a mesenchymal stem cell

A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions.

Growing community of inventors

Durham, NC, United States of America

Maria Mirotsou