Alfama, Inc.

Alfama-investigacao E Desenvolvimento De Produtos Farmaceuticos Lda

Cenix Bioscience Gmbh

Instituto De Medicina Molecular, Faculdade De Medicina Da Universidade De Lisboa

Maria M Mota

Ana Pamplona

Carlos C Romão

Gonçalo J L Bernardes

Michael Hannus

Ana Rodriguez

Silvia Giordano

Cecilie Martin

Margarida Cunha Rodrigues

Miguel Prudencio

Christina Dias Rodrigues

The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R, R, R, R, R, X, and Xare as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute resipiratory distress syndrome, which optionally may be associated with a malaria infection.

Ruthenium carbon monoxide releasing molecules and uses thereof

The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R, R, R, R, R, X, and Xare as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection. 

The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.

Use of inhibitors of scavenger receptor class proteins for the treatment of infectious diseases

A method for the prevention of infection of humans by plasmodium parasites is provided. The method consists of the application of compounds that interfere with the infection of hepatocytes by

Method for the prevention of malaria infection of humans by hepatocyte growth factor antagonists

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Lisbon, Portugal

Maria M Mota