Koninklijke Philips Corporation N.v.

Elekta, Inc.

The General Hospital Corporation

Maria Luiza Bondar

Alfonso Agatino Isola

Jens Wiegert

Heinrich Schulz

Steffen Renisch

Sven Kabus

Rolf Jürgen Weese

Harald Sepp Heese

Christoph Neukirchen

Hrishikesh Narayanrao Deshpande

Rolf Juergen Weese

Matthieu Frédéric Bal

Stéphane Allaire

Torbjoern Vik

Jacek Lukasz Kustra

Pedro Jorge Da Silva Rodrigues

Sergio Consoli

Nick Flaeschner

Vanda Lucia De Carvalho Vittorino De Almeida

Andreia Maria Araujo Trindade Rodrigues

Kay Sun

Ali Ajdari

Tom Brosch

In providing radiation therapy (RT) support, a patient specific toxicity risk is estimated for a RT side effect using a Bayesian network that receives as inputs values of biomarkers of the patient. A patient-specific RT plan is optimized with respect to parameters including the patient-specific toxicity risk. During delivery of RT according to the plan, at least one updated value is received for the biomarkers of the patient, and an updated patient-specific toxicity risk is estimated using the Bayesian network with the updated value(s). The Bayesian network biomarker nodes and a toxicity risk node representing the patient specific toxicity risk, and directed arcs with arc weights representing strengths of interdependencies between the nodes connected by the directed arcs. A graphical user interface (GUI) is provided via which a clinician may interact with the Bayesian network. A test recommendation may be initiated or updated for scheduling of a patient test based on the updated patient-specific toxicity risk.

Systems and methods to support personalization of cancer treatment for patients undergoing radiation therapy

Thereto a method and a system for planning radiation therapy are provided, as well as an arrangement for radiation therapy planning and a computer program product for carrying out the method. For planning the radiation therapy, the following steps are performed. Patient data of a subject to be treated is received as well as image data of the subject to be treated. The image data comprises anatomical image data of one or more organs at risk associated with the functioning of the immune system. Next, the patient 122 data and the image data are processed to obtain a risk score for the one or more organs at risk associated with the functioning of the immune system. The risk score is indicative of the risk of hematologic toxicity in the subject to be treated in response to the radiation therapy. Then the radiation therapy treatment is planned using the obtained risk score.

Planning radiation therapy using a personalized hematologic risk score

A system and a method for monitoring anatomical changes in a subject in radiation therapy are provided, as well as an arrangement for medical imaging and analysis and a computer program product for carrying out the method. For monitoring anatomical changes in a subject in radiation therapy, the following steps are performed. First anatomical image data and subsequent anatomical image data of the subject are received. The first anatomical image data and the subsequent anatomical image data are analyzed. This analysis comprises registering the subsequent anatomical data to the first anatomical data. Changes between the first anatomical image data and the subsequent anatomical image data are identified as change states, and the identified change states are matched to corresponding qualitative descriptions. A monitoring report is provided, which comprises the qualitative descriptions of the identified changes.

Automated qualitative description of anatomical changes in radiotherapy

The invention relates a system for assisting in planning a radiation therapy treatment provided using a treatment plan comprising irradiation parameters for controlling a delivery of radiation. The system is configured to (i) receive a first dose distribution, (ii) obtain a first objective function, which depends upon at least one parameter and a dose distribution, (iii) determine a first value of the parameter such that the first objective function fulfills a predefined criterion when being evaluated for the first value of the parameter and for a second dose distribution derived from the first dose distribution, (iii) provide the first objective function in connection with the first value of the at least one parameter to a user for modifying the first objective function to generate a second objective function, and (v) determine the treatment plan using the second objective function. Further, the invention relates to a corresponding method and computer program.

Radiation therapy planning

The invention relates to a planning apparatus for planning a radiation therapy. A medical image, in which a target to be irradiated is indicated, is reformatted based on ray geometries to be used during the radiation therapy to be planned, resulting in several reformatted medical images. Radiation therapy parameters being indicative of intensities of raysto be used for irradiating a targetare determined based on the reformatted medical images by using a neural network unit. This allows to determine high quality radiation therapy parameters and hence allows for an improved planning of a radiation therapy. In particular, radiation and absorptions physics can be captured better, which can lead to the improved quality.

Planning apparatus for planning a radiation therapy

The invention relates to a system for assisting in evaluating a contour of an anatomic structure () with respect to a dose distribution corresponding to a treatment plan for a radiation therapy treatment of a patient. The system comprises an evaluation unit particularly configured to evaluate the dose distribution in varying distances from the contour of the anatomic structure () to determine at least one point where the evaluated dose distribution fulfills a predetermined condition, and to determine the distance between the at least one point and the contour and/or to visualize the at least one point to a user of the system.

Evaluation of an anatomic structure with respect to a dose distribution in radiation therapy planning

The invention relates to a system and a method for evaluating a treatment plan for an external radiation therapy treatment, the treatment plan comprising parameters for controlling an external radiation therapy apparatus during the treatment. The system comprises a database storing historic treatment plans and storing for each historic treatment plan a quality parameter indicative of whether a deviation between a planned dose distribution and a measured dose distribution resulting from an execution of the treatment plan is within an acceptable limit. An evaluation unit determines a threshold value for each of a plurality of treatment plan metrics based on the historic treatment plans and the associated quality parameters. Further, the evaluation unit calculates a value of each of the metrics for the treatment plan and compares the value of each of the metrics with the threshold value determined for the respective metric.

Evaluation of dose accuracy of radiation therapy treatment plans

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Waalre, Netherlands

Maria Luiza Bondar