Distretto Tecnologico Sicilia Micro E Nano Sistemi S.c.a.r.l.

Consiglio Nazionale Delle Ricerche

Università Degli Studi Di Catania

Universita' Degli Studi Di Palermo

Maria Luisa Bondi'

Gaetano Giammona

Salvatore Cuzzocrea

Giovanna Pitarresi

Santa Viola

Anna Rita Blanco

Patrizia Saladino

Gennara Cavallaro

Grazia Maria Letizia Consoli

Emanuela Fabiola Craparo

Salvatore Papasergi

Patrizia Guarneri

Mariano Licciardi

Emanuela Esposito

Irene Ceidda

Guiseppe Granata

Clara La Marca

Giuseppe Granata

Irene Deidda

Filippo Drago

Clara La Marco

Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.

Nanostructured formulations for the delivery of silibinin and other active ingredients for treating ocular diseases

Growing community of inventors

Trabia, Italy

Maria Luisa Bondi'