Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Assistance Publique-Hopitaux De Paris

Université Paris Descartes

Imagine Institut Des Maladies Genetiques Necker Enfants Malades

Maria Leite De Maraes

Olivier Hermine

Marie Thérèse Rubio

Marie Bouillie

The present invention relates to a method for determining whether a candidate human transplant donor is at risk of inducing acute graft versus host disease (aGVHD) in a human transplant recipient, which may in turn allow the selection of a donor exhibiting no risk for the recipient. The present invention also relates to a method for adjusting the immunosuppressive treatment administered to a human transplanted recipient following its graft transplantation after having performing the method for determining risk of the invention. The methods comprise expanding the candidate donor's iNKT cells (invariant NKT cells) and determining the presence or absence of expansion of the CD4(&#x2212;) iNKT cell sub-population. In particular, CD3+CD4&#x2212; TCRV[alpha]24V[beta]11 cells are determined. Kits are disclosed.

Methods for determining the risk of acute graft versus host disease

Growing community of inventors

Paris, France

Maria Leite De Maraes