Cytrx Corporation

Egis Gyogyszergyar

Biorex Research & Development Co.

Mária Kürthy

László Ürögdi

Ede Márványos

Gábor Balogh

Laszlo Jaszlits

Ibolya Horváth

Péter Literáti Nagy

Zsolt Török

László Vígh

György Dormán

Beatrix Farkas

Andrea Jednákovits

Attila Glatz

Katalin Bíró

László Korányi

Éva Udvardy

Dénes Medzihradszky

Bea Mézes

Eszter Kovács

László Jaszlits

Mihály Barabás

Erzsébet Hegedüs

Marton Fekete

Katalin Szemeredi

Peter Matyus

Gyorgy Rabloczky

Ilona Bodi

Katalin Biro

Andras Varro

Andrea Jednakovits

Agnes Papp

Erzsebet Zara

Mihaly Barabas

Klara Czako

Jenö Szilbereky

Ildiko Varga

Andrea Jednakovics

Aniko Miklos

Gvorgy Schmidt

Ernö Duda

Luca Levay

Erzsebet Radvanyne

Istvanne Udvardy Nagy

Jenó Szilbereky

Ernó Duda

A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof

Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof

Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions

Racemic or optically active new 3(2H)-pyridazinone derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said 3(2H)-pyridazinone derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The new 3(2H)-pyridazinone derivatives according to the invention correspond to the general formula (I), ##STR1##

3(2H)-pyridazinone derivatives and process for the preparation thereof

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Budapest, Hungary

Mária Kürthy