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Canadian Blood Services

Maria I C Gyongyossy-Issa

William Norman Campbell

Dana Virginia Devine

Jerry Gongdu Zhang

Carlos A Del Carpio Munoz

Iren Constantinescu

Disclosed is a platelet additive solution (PAS) comprising a viscosity increasing agent. The use of a PAS comprising such a viscosity increasing agent, especially at concentrations effective to achieve a viscosity similar to that of blood plasma, promotes platelet recovery during extraction from pooled buffy coats and provides for easier platelet production by maintaining the red cell/platelet-rich-supernatant interface.

Platelet additive solution with a viscosity of 1.128-1.228 centipoise @ 37C comprising hydroxyethyl starch and methods of making and using

It is provided mimotope receptors and inhibitors that employ peptide mimics that mimic the shape and function of natural receptors and ligands, thus providing synthetic binding sites for ligands and receptors. Receptor mimics can be attached to carriers, such as liposomes, to act as synthetic platelets, for example, by providing multiple binding sites for binding to other (natural or synthetic) platelets or to the endothelium. Synthetic platelets would have virtually limitless shelf life and would not require disease screening prior to transfusion, thereby providing a solution to the perpetual platelet shortages, as well as the safety and storage issues associated with natural blood platelets.

Peptide mimotopes that inhibits interaction between a platelet receptor and a platelet receptor ligand

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Vancouver, Canada

Maria I C Gyongyossy-Issa