Ge Healthcare Bio-sciences Ab

Ge Healthcare Bioprocess R&d Ab

Maria Holm

Jean-Luc Maloisel

Bo-Lennart Johansson

Anders Larsson

Hans J Johansson

Hans Berg

Henrik Ihre

Philippe Busson

Anders Hagvall

Eva Holmgren

David Buckley

Jafar Saidzadeh

Dag Lindström

Asa Ek

The present invention relates to a chromatography ligand defined by the following formula R&#x2014;R&#x2014;N(R)&#x2014;R&#x2014;Rwherein Ris a substituted or non-substituted phenyl group; Ris a hydrocarbon chain comprising 0-4 carbon atoms; Ris a hydrocarbon chain comprising 1-3 carbon atoms; Ris a hydrocarbon chain comprising 1-5 carbon atoms; and Ris OH or H. The invention also comprises a separation matrix, comprising the described ligands coupled to a porous support, such as particles or a membrane. The ligand and matrix according to the invention is useful for purification of biomolecules or organic compounds, such as proteins, polypeptides, DNA etc. An advantageous use according to the invention is the purification of antibodies.

Chromatography ligand

Growing community of inventors

Almhult, Sweden

Maria Holm