Proteus Digital Health, Inc.

Otsuka Pharmaceutical Company, Limited

Maria Holen

Hooman Hafezi

Robert Duck

Timothy Robertson

Benedict Costello

Kityee Au-Yeung

Gregory Moon

Patricia Johnson

Raymond H Schmidt

Kit Yee Au-Yeung

Richard Huang

Alvin Thai

Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.

Highly reliable ingestible event markers and methods for using the same

Provided is an apparatus, system, and method for detecting a metal contaminant in a sensor-enabled dose form. According to the method, a sensor-enabled dose form is oriented in a predetermined orientation. The sensor-enabled dose form is received through an aperture of a metal detector. A detection signal is generated by the metal detector in response to receiving the sensor-enabled dose form through the aperture of the metal detector. The detection signal is compared to a predetermined threshold. The presence of a metal contaminant in the sensor-enabled dose form is determined based on the comparison of the detection signal and the predetermined threshold. In another method, the sensor-enabled dose form is first oriented in a first orientation and then in a second orientation. The apparatus includes a guide, a metal detector, and a comparator circuit. The system further includes a controller to reject contaminated sensor-enabled dose forms.

Metal detector apparatus, system, and method

Virtual dipole signal amplification for in-body devices, such as implantable and ingestible devices, is provided. Aspects of the in-body deployable antennas of the invention include antennas configured to go from a first configuration to a second configuration following placement in a living body, e.g., via ingestion or implantation. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.

In-body device with virtual dipole signal amplification

Pharmaceutical delivery systems for delivering dosages according to the present invention include a carrier component and a cap configured to seal an internal volume of the carrier component, wherein the cap includes a device that produces a unique current signature. Dosages prepared to be delivered according to embodiments of the invention find use in a variety of different applications, including clinical trials.

Pharmaceutical dosages delivery system

Growing community of inventors

Santa Clara, CA, United States of America

Maria Holen