Pamgene Bv

Stichting Het Nederlands Kanker Instituut

Pamegene B.v.

Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg

Maria Helena Hilhorst

Robby Ruijtenbeek

Richard De Wijn

Herman Blok

Colin John Ingham

Arzu Umar

Johannes Albert Foekens

Johannes Wilhelmus Maria Martens

Michael Maria Van Den Heuvel

Houke Marian Klomp

Hendrik Sibolt Van Damme

Saskia Maria Van Der Vies

Jeroen Joseph Maria Hoozemans

The present invention relates to a method for determining the estrogen receptor status of patients suffering from breast cancer. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with breast cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples obtained from patients diagnosed with breast cancer.

Method for determining the estrogen receptor status of breast cancer

The present invention relates to a method for determining the survival prognosis of patients suffering from non-small cell lung cancer. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels in response to a kinase inhibitor and profiles in samples obtained from patients diagnosed with non-small cell lung cancer. The present invention also provides methods for predicting the response of a patient diagnosed with non-small cell lung cancer to a medicament.

Method for determining survival prognosis of patients suffering from non-small cell lung cancer (NSCLC)

The present invention relates to a method for determining or predicting the response of a patient diagnosed with non small cell lung cancer to targeted pharmacotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with non small cell lung cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles and inhibitions thereof by drugs in samples of said patients.

Method for predicting the response of non-small cell lung cancer patients to targeted pharmacotherapy

The present invention relates to methods for screening of cellular responses of cellular components comprising: (a) providing cellular components on the surface of a substrate, said substrate having immobilized thereon an array of detector molecules; (b) delivering test compounds to positions on the substrate corresponding to the arrayed detector molecules on the surface of said solid substrate; (c) incubating said test compounds with said cellular components on the surface of the solid support, under conditions allowing the induction of cellular responses; (d) assaying said cellular responses; and, identifying and characterizing the cellular responses induced by said test compounds. The present invention further relates to the uses of said methods as well as microarrays and kits for carrying out said methods.

Method for high throughput cell-based assays using versatile living microarrays

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Wageningen, Netherlands

Maria Helena Hilhorst