Schering Corporation

Maria-Grazia Roncarolo

Rene De Waal Malefyt

Jan E De Vries

Rosa Bacchetta

Herve M Groux

Interleukin-10 for producing a population of cells which are capable of inhibiting or suppressing reactions to alloantigens, for example in graft-versus-host disease or tissue rejection, is described. Interleukin-10 for reducing responses in mixed lymphocyte response (MLR) is also described. Exogenous or induced endogenous IL-10 may be used for the inhibition or suppression of the reactions to alloantigens.

Methods for modulating antigen-specific immune responses

Use of interleukin-10 to produce a population of suppressor cells

The invention provides improved methods of prenatal diagnosis that can be performed earlier in pregnancy, and/or with greater safety, and/or rapidity, and/or with greater accuracy than conventional methods. A volume of amniotic fluid containing fetal cells is extracted from a pregnant woman, and the fetal T-cells are propagated in a culture medium comprising one or more cytokines. The fetal T-cells are then diagnosed for genetic defects.

Cytokine-induced proliferation of amniotic t-cells

Prenatal diagnosis by cytokine-induced proliferation of fetal T-cells

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Los Altos, CA, United States of America

Maria-Grazia Roncarolo