Ospedale San Raffaele S.r.l.

Fondazione Telethon

Other

Schering Corporation

Yale University

Fondazione Centro San Raffaele Del Monte Tabor

Fondazione Centro San Raffaele

San Raffaele S.r.l.

Maria Grazia Roncarolo

Silvia Adriana Gregori

Rosa Bacchetta

Manuela Battaglia

Richard A Flavell

Rene De Waal Malefyt

Luigi Naldini

Alessio Cantore

Andrea Annoni

Nicola Gagliani

Samuel Huber

Chiara Francesca Magnani

Megan K Levings

Silvia Gregori

The invention is based upon the discovery that T regulatory type 1 (Tr1) cells express particular cell surface markers that allow for their selection, enrichment, isolation, purification and administration. The ability to use the particular markers described herein to select, enrich, isolate, purify and administer Tr1 cells allows for improved methods of Tr1 therapies for treating a wide variety of diseases and disorders.

Compositions and methods for diminishing an immune response

The present invention relates to a tolerogenic dendritic cell population (Tr-DC) capable of generating a population of T cells having regulatory activity, method of production and uses thereof. Furthermore, soluble HLA-G promotes the differentiation of a population of T cells with regulatory activity.

Tolerogenic dendritic cells, method for their production and uses therof

A gene vector adapted for transient expression of a transgene in a peripheral organ cell comprising a regulatory sequence operably linked to a transgene wherein the regulatory sequence prevents or reduces expression of said transgene in hematopoietic lineage cells.

Gene vector for inducing transgene-specific immune tolerance

A method for generating/expanding in vitro a CD4CD25T regulatory (Tr) cell and the use thereof in the treatment of diseases associated with a cell-mediated immune response (including T- and antibody-mediated responses).

Method for expanding Cd4+ Cd25+ T regulator cells

The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of diseases involving an excessive, dysfunctional or uncontrolled immune responses mediated by T cells.

Method for the treatment of automimmune diseases comprising administering rapamycin and IL-10

Methods for increasing yields of Tr1 cells, useful, e.g., in transplantation contexts. Use of interferon and IL-15 are described.

Regulatory T cells; methods

Growing community of inventors

Milan, Italy

Maria Grazia Roncarolo