Industriale Chimica S.r.l.

Maria Giovanna Luoni

Roberto Lenna

Francesco Barbieri

Johannes Bernardus Maria Rewinkel

Monica Noseda

A process is described wherein, by employing 17&#x3b1;-(3-hydroxypropyl)-6&#x3b2;,7&#x3b2;;15&#x3b2;,16&#x3b2;-dimethylene-5&#x3b2;-androstane-3&#x3b2;,5,17&#x3b2;-triol (II) as starting product, in a single stage reaction there is obtained drospirenone, (I), a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic action, that is useful for preparing pharmaceutical compositions with contraceptive action. 

Process for the preparation of drospirenone

A process is disclosed wherein, using either 17a-(3-hydroxypropyl)-6p,7p;15p,16p-dimethylene-5p-androstane-3p,5,17p-triol (II) or 3&#x3b2;,5^&#xef;I^&#x3ba;^-6&#x3b2;,7&#x3b2;;15&#x3b2;,16&#x3b2;-dimethylene-5&#x3b2;,17&#x3b1;-pregnane-21,17-carbolactone (III) as starting material, through a single-step reaction it is obtained drospirenone (I), a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions with contraceptive action. 

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Cardano al Campo, Italy

Maria Giovanna Luoni