Pharma Mar, S.a.

Pharmamar

Maria Flores

Ignacio Manzanares

Pilar Gallego

Carmen Cuevas

Simon Munt

Maria Zarzuelo

Valentin Martinez

Andrés Francesch

Andres Francesh

Jose Luis Chicharro

Carolina Fernandez

Carolina Fernández

José Luis Chicharro

Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula Ia.: wherein the substituent groups take various permitted meanings.

Antitumoral derivatives of ET-743

This invention relates to antitumoral ecteinascidin derivatives that contain a fused ecteinascidin five ring system with a 1,4-bridge having the structure of formula (VIa) or (VIb) as described herein and compounds in which the &#x2014;NHor &#x2014;OH of the 1,4-bridge is derivatized, and related pharmaceutical compositions and methods. Such ecteinascidin derivatives include, but are not limited to, those compounds having formula (XVIIb): in which Rand Rtogether form a group of formula (VIa) or (VIb) as described herein, and R, R, R, R, R, R, and Rare as defined herein.

Anititumoral ecteinascidin derivatives

Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula (Ia) wherein the substituent groups take various permitted meanings. 

This invention relates to compounds of the formula: 

Antitumoral ecteinascidin derivatives

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Sevilla, Spain

Maria Flores