Centro De Immunologia Molecular

Maria Del Carmen Luzardo Lorenzo

Circe Mesa Pardillo

Luis Enrique Fernández Molina

Liem Canet Santos

Rady Judith Laboroe Quintana

Isabel Fabiola Pazos Santos

Maria Eugenia Alonso Biosca

Carlos Manuel Alvarez Valcárcel

Mayra Tejuca Martínez

Maria Eliana Lanio Ruiz

Yoelys Cruz Leal

Aisel Valle Garay

The present invention relates to the field of biotechnology applied to human health. The invention describes a vaccine vehicle which toxins from eukaryotic organisms are encapsulated in liposomes with multiple lipid layers, obtained by means of the process of dehydration/rehydration, the lipid composition of which is dipalmitoylphosphatidylcholine:cholesterol in a molar ration of 1:1, which are designed for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. The compositions described allow modulation of the specific CTL immune response to one or more antigens co-encapsulated in the liposomes that containing the toxin. The vaccine vehicle of the present invention presents advantages as compared with others described in the prior art owning to the robust and functional nature of the immune response induced and also the immunomodulating properties thereof.

Vaccine composition based on sticholysin encapsulated into liposomes

Growing community of inventors

La Habana, Cuba

Maria Del Carmen Luzardo Lorenzo