Centro De Ingenieria Genetica Y Biotecnologia

Maria Del Carmen Dominguez Horta

Norailys Lorenzo Perez

Vivian Morera Cordova

Gabriel Ramón Padrón Palomares

Ariadna Hernández Garcia

Ariana Barberá Betancourt

Gabriel Ramon Padron Palomares

Carelia Cosme Diaz

Viviana Falcon Cama

Nelson J Merino Garcia

Ariel Vázquez Bonachea

Nelia López Marin

José Suárez Alba

Ivon Menendez Valdes

Ariana Barbera Betancourt

The present invention is related with the field of the medicine, particularly with the use of an APL peptide or its analogues derived from the human heat shock protein of 60 kDa, for the manufacture of a pharmaceutical composition for the treatment of Crohn's disease, ulcerative colitis and diabetes mellitus type 1. This peptide is biodistributed into the gastrointestinal tract and also promotes the induction of apoptosis in activated intestinal lamina propria and peripheral blood T cells of patients with Crohn's disease. Furthermore, this peptide induces apoptosis in mononuclear cells of patients with diabetes mellitus type 1.

Method of inducing T cell apoptosis by administering Altered Peptide Ligand

Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.

Altered peptide ligand derived from HSP60 and pharmaceutical compositions

Growing community of inventors

Ciudad de la Habana, Cuba

Maria Del Carmen Dominguez Horta