Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Maria David Nee Kenez

Sandor Virag

Gabor Nagy

Katalin Marmarosi Nee Kellner

Gabor Horvath

Sandor Bozsoky

Marianna Pongor Nee Csakvari

The invention relates to synergistic antiphlogistic pharmaceutical compositions comprising a pyrido [1,2-a]-pyrimidine derivative of the Formula I ##STR1## wherein R.sup.1 and R.sup.2 are lower alkyl and R.sup.3 stands for lower alkoxycarbonyl or carbamoyl and the dotted line represents an optionally hydrogenated band or a salt or quaternary salt thereof and 1-[p-chloro-benzoly]-2-methyl-5-methoxy-indolyl-3-acetic acid of the Formula II ##STR2## The advantage of the compositions is that as a result of the synergistic activity of the compound of the Formula I, the antiphlogistic Indomethacin of the Formula II can be administered in a significantly lower doses and consequently the unfavorable side effects of the latter compound are mitigated.

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Budapest, Hungary

Maria David Nee Kenez