Pharmacia Italia S.p.a.

Pharmacia & Upjohn

Farmitalia Carlo Erba S.r.l.

Nerviano Medical Sciences S.r.l.

Maria Cristina Geroni

Italo Beria

Paolo Cozzi

Antonino Suarato

Michele Caruso

Marina Caldarelli

Marina Ripamonti

Enrico Pesenti

Pier Giovanni Baraldi

Nicola Mongelli

Marina Ciomei

Alessandro Martini

Giovanni Biasoli

Maria Grandi

Romeo Romagnoli

Paolo Elia Cappella

Giulia Pennella

Olga Valota

The present invention relates to pharmaceutical composition containing nemorubicin hydrochloride incorporated in microspheres. The compositions are useful for chemoembolization, particularly for loco regional treatment of tumors.

Pharmaceutical composition of an anthracycline

Compounds which are &#x3b1;-halogenoacryloyl distamycin derivatives of formula (I) wherein Ris a bromine or chlorine atom; Ris a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies.

Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione

The present invention refers to distamycin and derivatives thereof, such as bromo- or chloro-acryloyl derivatives of distamycin, which are conjugated with glutathione, to a process for their preparation and to pharmaceutical compositions thereof. The compounds of the invention are endowed with a remarkable antitumor activity and are thus useful in therapy in the treatment of cancer.

Glutathiaone conjugates with distamycin derivatives having antitumoral activity

Compounds which are cinnamoyl distamycin derivatives of formula (I), wherein n is 2, 3, or 4; R is C -C alkyl or C -C haloalkyl; R and R , which are the same or different, are selected from hydrogen, C -C alkyl optionally substituted by one or more fluorine atoms; and C -C alkoxy; X is a halogen atom; Y and Z are the same or different and are selected, independently for each heterocyclic ring of the polyheterocyclic chain, from N and CH; B is selected from (a), (b), (c), (d), (e), (f), (g)and (h) wherein R , R , R , R and R are, independently from each other, hydrogen or C -C alkyl; or pharmaceutically acceptable salts thereof; provided that at least one of the heterocyclic rings within the polyheterocyclic chain is other than pyrrole; are useful as antitumor agents.

Cinnamoyl distamycin analogous derivatives, process for their preparation, and their use as antitumor agents

The present invention relates to combined preparations comprising a morpholinyl anthracycline administered in combination anticancer agents chosen from an alkylating agent, an antimetabolite, a topoisomerase II inihbitor, a topoisomerase I inhibitor, an antimitotic drug and a platinum derivative, which are useful anticancer therapy, particularly in the treatment of a primary or metastatic liver cancer.

Combined preparations comprising morpholine anthracyclines and anticancer agent

The present invention relates to combined preparations comprising a morpholinyl anthracycline administered in combination anticancer agents chosen from an alkylating agent, an antimetabolite, a topoisomerase II inhibitor, a topoisomerase I inhibitor, an antimitotic drug and a platinum derivative, which are useful anticancer therapy, particularly in the treatment of a primary or metastatic liver cancer.

The present invention relates to anthracycline glycosides, to a process for their preparation and to pharmaceutical compositions containing the same.

13-dihydro-3&prime; aziridino anthracyclines

A compound which is a distamycin derivative of formula (I), wherein n is 2, 3 or 4; R,is C,-C,alkyl or C,-C,haloalkyl; R,and R,, which may be the same or different, are each hydrogen, C,-C,alkyl optionally substituted by one or more fluorine atoms, or C,-C,alkoxy; X is a halogen atom; B is selected from (A, B, C, D, E, F, G, H, I, J and K); wherein R,, R,, R,, R,, R,, R,, and R,, which may be the same or different, are each hydrogen or C,-C,alkyl, and m is 0, 1, or 2; or a pharmaceutically acceptable salt thereof. Such compounds are useful as antineoplastic and antiviral agents.

Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Distamycin derivatives, process for preparing them, and their use as

The invention relates to naphthalenesulfonic-pyrrolecarboxamido compounds of formula ##STR1## wherein n is zero or an integer of 1 to 3; R is a sulfonic acid residue; m is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof, which are active as antiviral agents, in particular against Human Immunodeficiency Virus

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Milan, Italy

Maria Cristina Geroni