Bridgestone Europe Nv/sa

Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.r.l.

Maria Cecilia Palumbi

Philip Jones

Rita Scarpelli

Raffaele Di Ronza

Giovanna Pescatore

Ester Muraglia

Olaf Kinzel

Federica Ferrigno

Francesco Iozia

Savina Malancona

Maria Cristina Caccami

Jose Ignacio Martin Hernando

Danila Branca

Giacomo Andreini

Roberto Lombardi

A method to manufacture an electronic device to be applied to rubber article. The device comprises an electronic element, two layers of thermoplastic material which are arranged in a sandwich-like manner so as to contain, between one another, the electronic element, and at least an outer rubber layer arranged to cover an outer surface of at least one of the respective thermoplastic layers. The method comprises a preliminary step comprising (a) a deposition operation, during which an adhesive solution consisting of a basic water solution comprising a latex of an elastomer rubber and a combination of resorcinol and formaldehyde is applied on at least one outer surface of one of the layers of thermoplastic material; and (b) a heating operation, during which the layers of thermoplastic material on which the adhesive solution was applied are kept at a temperature ranging from 120 to 230° C. for an amount of time ranging from 2 to 15 min.

Method to manufacture an electronic device for a rubber article

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract. 

Saturated bicyclic heterocyclic derivatives as SMO antagonists

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Rome, Italy

Maria Cecilia Palumbi